Neurodegeneration and the Gothenburg MCI study
DOI:
https://doi.org/10.36505/ExLing-2019/10/0017/000379Keywords:
neurodegeneration, mild cognitive impairment, dementiaAbstract
Mild cognitive impairment (MCI) is the stage between the expected cognitive decline of a normal aging population and the more serious decline of dementia. Typically, the performance of a cognitive test is considered impaired if it is $\ge 1.5$ standard deviations below normal controls. The ongoing Gothenburg mild cognitive impairment (MCI) study is an attempt to conduct longitudinal in-depth phenotyping of patients with different forms and degrees of cognitive impairment using various assessment tools. This paper presents the background of the linguistic and extra-linguistic parameters for early detection of cognitive impairment-project, a research which is partly based on data acquired at the Gothenburg MCI-study.
References
Eckerström, C., Olsson, E., Bjerke, M., Malmgren, H., Edman, Å., Wallin, A., Nordlund, A. 2013. A Combination of Neuropsychological, Neuroimaging, and Cerebrospinal Fluid Markers Predicts Conversion from Mild Cognitive Impairment to Dementia. J of Alzheimer’s Disease 36. 421–431. DOI 10.3233/JAD-122440.
Erkkinen, M.G., Kim, M.O., schwind, M.D. 2018. Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. Cold Spring Harb Perspect Biol. 10 (4). pii: a033118. doi: 10.1101/cshperspect.a033118.
Fraser, KC., Lundholm Fors, K., Kokkinakis, D., Nordlund, A. 2017. An analysis of eye-movements during reading for the detection of mild cognitive impairment. Conference on Empirical Methods in Natural Language Processing (EMNLP). Pp. 1016–1026. Copenhagen, Denmark
Heemels, M-T. 2016. Neurodegenerative disease. Nature. 10;539(7628):179. doi: 10.1038/539179a.
Kokkinakis, D., Lundholm Fors, K., Nordlund, A. 2016. Data Resource Acquisition from People at Various Stages of Cognitive Decline - Design and Exploration Considerations. 7th International Workshop on Health Text Mining and Information Analysis (LOUHI). An EMNLP Workshop. Texas, USA.
Linz, N., Lundholm Fors, K., Lindsay, H., Eckerström, M., Alexandersson, J., kkinakis, D. 2019. Temporal Analysis of Semantic Verbal Fluency Tasks in Persons with Subjective and Mild Cognitive Impairment. Sixth Workshop on Computational Linguistics and Clinical Psychology: Reconciling Outcomes. Minneapolis, USA.
Nordlund, A., Rolstad, S., Hellström, P., Sjögren, M., Hansen, S., llin, A. 2005. The Goteborg MCI study: mild cognitive impairment is a heterogeneous condition. J Neurol Neurosurg Psychiatry. 76(11):1485-90.
Nordlund, A., Rolstad, S., Klang, O., Lind, K., Hansen, S., llin, A. 2007. Cognitive profiles of mild cognitive impairment with and without vascular disease. Neuropsychology. 21(6):706-12. PMID: 17983284.
Nordlund, A., Rolstad, S., Klang, O., Lind, K., Pedersen, M., Blennow, K., Edman, A., Hansen, S., llin A. 2008. Episodic memory and speed/attention deficits are associated with Alzheimer-typical CSF abnormalities in MCI. J Int Neuropsychol Soc. 14(4):582-90. doi: 10.1017/S135561770808079X.
Nordlund, A., Göthlin, M., llin, A. 2011. Vascular disease, Alzheimer's disease biomarkers and cognition in mild cognitive impairment: additive or synergetic effects? Dement Geriatr Cogn Disord. 32(4):250-6. doi: 10.1159/000334653.
Nordlund, A., Rolstad, S., Göthlin, M., Edman, A., Hansen, S., llin, A. 2010. Cognitive profiles of incipient dementia in the Goteborg MCI study. Dement Geriatr Cogn Disord. 30(5):403-10. doi: 10.1159/000321352.
Petersen, R.C., Smith, G.E., Waring, S.C., Ivnik, R.J., Kokmen, E., ngelos, E.G. 1997. Aging, memory, and mild cognitive impairment. Int Psychogeriatr. 9 Suppl 1:65-9.
Themistocleous, C., Eckerström, M., kkinakis, D. 2018. Diagnosis of Mild Cognitive Impairment from Speech in Swedish using Deep Sequential Neural Networks. Frontiers in Neurology, section Neurodegeneration. doi: 10.3389/fneur.2018.00975.
Wallin, A., Nordlund, A., Jonsson, M., Lind, K., Edman, Å., Göthlin, M., Stålhammar, J., Eckerström, M., Kern, S., Börjesson-Hanson, A., Carlsson, M., Olsson, E., Zetterberg, H., Blennow, K., Svensson, J., Öhrfelt, A., Bjerke, M., Rolstad, S., kerström, C. 2016. The Gothenburg MCI study: Design and distribution of Alzheimer's disease and subcortical vascular disease diagnoses from baseline to 6-year follow-up. J Cereb Blood Flow Metab. 36(1):114-31.
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